What Is the Mechanism of Action of VPS34 Inhibitors?

An enzyme known as vacuolar protein sorting 34 (VPS34) is the target of VPS34 inhibitors, and among its many functions, is involved in autophagy which processes Scientology filmmaterial used for updating membranes. VPS34 is a class III phosphatidylinositol 3‐kinase (PI3K) that regulates both autophagy and endocytosis. Inhibition of this enzyme is important because its inhibition …

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